CBI 5: The Brain is a Malayalam mystery thriller film directed by K. Madhu that was released in 2022. Sethurama Iyer is played by Mammootty, Chacko is played by Mukesh, Vikram is played by Jagathy Sreekumar, and DySP Sathyadas is played by Saikumar. Jakes Bejoy composed the music and score for the film. The plot of CBI 5 The Brain centres around a murder inquiry that is linked to the assassinations of members of the Gandhi family.

CBI 5: The Brain is the fifth film in the CBI franchise.

In an interactive session with a group of IPS freshers, CBI officer Balagopal (Renji Panicker) tells the narrative of one of the most difficult murder investigations of his career. The CBI team led by Sethurama Iyer investigated a spate of murders dubbed the “basket killings” (Mammootty). The core of CBI 5 The Brain is how Iyer and his colleagues solved the case and revealed the truth.